Prebiotics are used by the gut microbiota creating metabolites that exert a positive
effect on the host (postbiotics). Prebiotics are available on the market for human and
animal consumption and may induce differential effects on the host's health and
metabolism. They can be tested by in vitro
Last updated on: 16-07-2020 - 15:02
Contact: Nadia Everaert
Organisation: University of Liège (ULiège)
Status: Published in peer reviewed journal
Cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) offer an attractive platform for cardiovascular research, including disease modeling, drug toxicity testing and development of regenerative therapies. Patient-specific iPSC-CMs are very useful to study disease pathogenesis and
Last updated on: 30-06-2020 - 14:13
Contact: Maaike Alaerts
Organisation: University of Antwerp (UAntwerpen)
Status: Still in development, Internally validated
Vascular smooth muscle cell (VSMC) deficiency plays a pivotal role in aneurysm development. Unfortunately, access to native VSMCs of patients and (particularly) control individuals is extremely limited. It has been shown that iPSC-derived VSMCs recapitulate the yet known disease processes very well.
Last updated on: 03-06-2020 - 13:51
Contact: Aline Verstraeten
Organisation: University of Antwerp (UAntwerpen)
Status: Still in development, Internally validated
Reverse pharmacology is a high-throughput in vitro method to characterise ligand-receptor interactions. In this method, a receptor of interest is expressed in a heterologous cell line and used as a hook to fish out its ligand(s) from a library of synthetic compounds. Receptor activation is measured
Last updated on: 17-04-2020 - 09:56
Contact: Isabel Beets
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
Computational Fluid Dynamics (CFD) is being applied to characterize the fluid flow in different applications. CFD has obtained significant interest in both the medical and engineering community because of its non-invasive character. It can predict the fluid flow characteristics when one or multiple
Last updated on: 10-04-2020 - 09:22
Contact: Mohammad Rahimi Gorji
Organisation: Ghent University (UGent)
Status: Still in development, Published in peer reviewed journal
Performing biopredictive dissolution tests in in vitro models that are frequently used in pharmaceutical and academic institutions and using these in vitro dissolution data as input for PBPK models to predict the systemic exposure of the drug in humans/patients.
Last updated on: 08-04-2020 - 17:29
Contact: Bart Hens
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
We study the influence of food parameters on the digestive kinetics of diverse nutrients throughout the upper gastrointestinal tract. For this, we use a static in vitro digestion protocol based on the standardized, consensus method recommended by the INFOGEST consortium. Briefly, the food is first
Last updated on: 31-03-2020 - 21:01
Contact: Tara Grauwet
Organisation: Katholieke Universiteit Leuven (KUL)
Partners: INFOGEST consortium
Status: Published in peer reviewed journal
The objective of this ex-vivo model is to study the initial pulp-tissue reaction of the human pulp tissue to different pulp-capping materials.
Methodology: Freshly-extracted (mainly due to orthodontic reasons) healthy human teeth (impacted third molars) from young individuals (15-20 years old)
Last updated on: 24-03-2020 - 16:32
Contact: Mariano Pedano
Organisation: Katholieke Universiteit Leuven (KUL)
Partners: Aix-Marseille University
Status: History of use, Internally validated, Published in peer reviewed journal
Design and fabrication of microfluidic devices that allow manipulation and analysis of (single) cells. Droplet-based as well as digital microfluidics can be applied and are suitable for a wide variety of (non-adherent) cells. Different materials can be used for the fabrication of the microfluidic
Last updated on: 10-03-2020 - 14:54
Contact: Cannot be disclosed
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Still in development, Published in peer reviewed journal
Organotypic epithelial raft cultures accurately reproduce the process of epithelial differentiation in vitro and can be prepared from normal keratinocytes, explanted epithelial tissue, or established cell lines. Normal primary human keratinocytes (PHKs) stratify and fully differentiate in a manner
Last updated on: 04-03-2020 - 14:34
Contact: Graciela Andrei
Organisation: Katholieke Universiteit Leuven (KUL)
Status: History of use, Internally validated, Published in peer reviewed journal
