Cerebellar brain slice model

Scope of the method

The Method relates to
  • Animal health
  • Human health
The Method is situated in
  • Basic Research
Type of method
  • In vitro - Ex vivo
This method makes use of
  • Animal derived cells / tissues / organs
Species from which cells/tissues/organs are derived
Mus Musculus
Type of cells/tissues/organs
Brain (cerebellum)


Method keywords
  • brainslices
  • cell culture
  • isolation
  • mouse
Scientific area keywords
  • basic research
  • fundamental research
  • neuroscience
  • myelin
Method description

This method describes the steps from a living mouse to a multi-cellular brain slice model where complex cellular interactions can be evaluated.

Method status
  • Still in development

Pros, cons & Future potential


By maintaining brain morphology and ultrastructurally the brain cells present, a complex multicellular system is being formed where the interplay between different cells can be evaluated to identify novel remyelinating therapeutics, targets,…

  • Inter-species differences ;
  • Terminal experiment for the lab animal ;
  • Requires a training period due to the susceptibility of the brain slices to cell death.

References, associated documents and other information

Associated documents
Cerebellar brain slices.docx

Contact person

Melissa Schepers


University of Hasselt (UHasselt)
Biomed Neuro-Immune Connection and Repair
Flemish Region