News & Events

This webinar will discuss the creation and use of the Source-to-Outcome framework. Doug Wolf, Syngenta, will describe how the framework facilitated application of a NAM to estimate the human equivalent concentration for inhalation risk assessment of the broad-spectrum fungicide chlorothalonil. The risk assessment was based upon the relevant aerosol characterization, respiratory dosimetry modeling, and endpoints derived from an in vitro assay using human respiratory epithelial tissue.

This webinar is part of the series 'DyNAMic discussions'. During this session, two speakers will present their work:

• Richard Judson, PhD, US EPA Office of Research and Development: Availability of New Approach Methodologies (NAMs) in the Endocrine Disruptor Screening Program (EDSP)
• Tara Barton-Maclaren, PhD, Health Canada: Exploring the Use of New Approach Methods for Screening and Assessment of Endocrine Disrupting Chemicals under Canada’s Chemicals Management Plan

This conference will focus on advanced and predictive 3D cell culture models and more specifically on the latest trends in development, biology and applications of organoids, the biology in Microphysiological Systems, the path from 3D cell cultures to cell-based therapies, as well as enabling technologies for standardisation and scalability.

Under an EPAA supported and funded project, a consortium of 14 pharmaceutical companies, the Medicines Evaluation Board (MEB) and the NC3Rs conducted a study to evaluate whether a 6-month toxicity study is still necessary to assess the long-term safety of mAbs.

The aim of this webinar is to provide an overview of the two recent publications from the project, discussing key results and recommendations.

This congress is an excellent opportunity to:

• Hear from leading 3D cell culture experts regarding scaffold and spheroid applications in personalised medicine, disease modelling, and drug discovery;
• Gain insights into novel tools and biofabrication techniques for scaffold creation, 3D bioprinting, and microphysiological system;
• Understand novel strategies to address anatomy vs. function, learning to choose the best model for the application, and challenges.

During this webinar, 3 speakers will present their work within different international institutes:

•     Dr. Aysha Akhtar: 'Why we must replace animal testing and how to do it – first steps in the U.S.'
•     Prof. Dr. Merel Ritskes-Hoitinga: 'Accelerating the transition to an animal-testing-free world: how can we achieve this together?'
•     Tilly Metz: 'Phasing out animal experiments in the EU: a European Parliament perspective'

The conference will include a variety of 3Rs content with a focus on improving rigor and translatability in biomedical research through the robust incorporation of the 3Rs. It will explore the potential for integrating translational digital biomarkers, machine learning and non-animal technologies to advance rigor and translation. 

The conference will include sessions on

• The Changing 3Rs Landscape
• Key 3Rs Technologies
• Microphysiological Systems
• In Silico Models
• 3Rs Opportunities & Tools
• ...