The chick chorioallantoic membrane (CAM) model is particularly attractive to study short-term xenografting of human ovarian tissue. Its angiogenic potential and natural immunodeficiency allow scrutiny of early follicle activation and loss and graft revascularization mechanisms. Chick embryo
Last updated on: 14-02-2024 - 17:24
Contact: Luciana Cacciottola
Organisation: Université Catholique de Louvain (UCL)
Status: Internally validated, Published in peer reviewed journal
The culture of primary human synoviocytes provides an excellent cellular model for studying the normal and pathological physiology of synoviocytes and the development of joint diseases. Human primary synoviocytes can either be provided by commercial suppliers or isolated from fresh biological
Last updated on: 17-01-2024 - 11:32
Fiber biopersistence is a key factor in understanding the pathogenicity of man-made vitreous fibres (MMVF). Today, compliance to Note Q in Annex VI of Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures may only be demonstrated via in vivo
Last updated on: 19-12-2023 - 19:17
Contact: Léa Hiéronimus
Organisation: Eurima is the European Insulation Manufacturers Association
Status: Still in development, Internally validated, Published in peer reviewed journal
Alkaptonuria (AKU) is a rare inborn error of metabolism caused by a defective homogentisate 1,2-dioxygenase (HGD), an enzyme involved in the tyrosine degradation pathway. Loss of HGD function leads to the accumulation of homogentisic acid (HGA) in connective body tissues in a process called
Last updated on: 06-12-2023 - 14:45
Contact: Sien Lequeue
Organisation: Vrije Universiteit Brussel (VUB)
Partners: RWTH Aachen
Status: Published in peer reviewed journal
More than 3 million deaths worldwide are linked to excessive alcohol consumption. Alcohol abuse associated gut barrier dysfunction is thought to play an important role in the development of alcohol-associated liver disease. Although some aspects that contribute to this process have been elucidated,
Last updated on: 30-10-2023 - 10:05
Contact: Ami Gloria Toulehohoun
Organisation: Université Catholique de Louvain (UCL)
Partners: UCLouvain, Cliniques universitaires Saint-Luc, UCLouvain
Status: Still in development
Endotoxins are lipopolysaccharides anchored at the outer membrane of gram-negative bacteria. These pyrogenic compounds can be introduced in pharmaceutical products during their manufacture and could induce severe physiological reactions in humans. This is why endotoxins are dosed, in order to assure
Last updated on: 28-09-2023 - 11:59
Contact: Flore Laurent
Organisation: Sciensano
Status: Internally validated, Validated by an external party (e.g. OECD, EURL ECVAM,…)
The maturation of the human brain shows species-specific differences of neoteny when compared to lower mammals. This process encompass a time window that expands from late embryonic stages to early adolescence. Major features of brain maturation are the acquisition of phenotypic complex traits such
Last updated on: 25-09-2023 - 14:38
Contact: Ira Espuny Camacho
Organisation: University of Liège (ULiège)
Status: Still in development, History of use
In contrast to human medicine, standard imaging techniques for cardiac interventions, namely fluoroscopy, CT and MRI, cannot be used in horses because the size of their thorax is too large for the gantry (CT and MRI) or results in insufficient detail (fluoroscopy). Therefore, echocardiography is
Last updated on: 20-09-2023 - 10:28
Severely burned skin can exhibit serious contractions that may negatively impact the mobility of joints of patients. The method deals with post-burn evolution of skin, in which one considers the balance of momentum, cells, collagen and chemokines. The balances are represented in terms of partial
Last updated on: 05-09-2023 - 11:43
Contact: Fred Vermolen
Organisation: University of Hasselt (UHasselt)
Status: Still in development, Internally validated, Published in peer reviewed journal
UHDR irradiations show healthy tissue sparing effect known as the FLASH effect. Since 2014, the FLASH effect is investigated worldwide to understand how it works and how to trigger it. The FLASH effect is defined as an in vivo effect. However, in vivo models are often expensive and time-consuming.
Last updated on: 05-09-2023 - 08:45
