Using respirometry (oxygen and pH, XF96 Analyzer), computer assisted cell analysis, and specific substrates and stressors, mitochondrial function and metabolic changes in a diverse set of cell lines can be measured. Relevant to study substrate preferences, acute and chronic effects of toxic
Last updated on: 15-02-2022 - 15:31
Contact: Charlotte Grootaert
Organisation: Ghent University (UGent)
Status: History of use, Published in peer reviewed journal
Spheroids are three-dimensional cellular models with widespread basic and translational application across academia and industry. However, methodological transparency and guidelines for spheroid research have not yet been established. The MISpheroID Consortium developed a crowdsourcing knowledgebase
Last updated on: 11-02-2022 - 10:29
Contact: Olivier De Wever
Organisation: Ghent University (UGent)
Status: Published in peer reviewed journal
Fever-inducing substances need to be traced in medical packaging material. To do so, in the past, rabbits were often exposed to these substances. Causing enormous amounts of animal suffering. Nowadays this test has been largely replaced by the so-called LAL (Limulus amebocyte lysate) test, which
Last updated on: 09-02-2022 - 16:11
The lack of a continuous in vitro culture system for P. vivax has made it impossible to genetically engineer P. vivax for mechanistic research studies. One alternative that is being used is the infection of non-human primates, however this is restricted to few laboratories across the world. An
Last updated on: 08-02-2022 - 14:04
Contact: Anna Rosanas-Urgell
Organisation: Institute of Tropical Medicine, Antwerp
Partners: Royal Veterinary College
Status: Internally validated, Published in peer reviewed journal
Reflex tests on fish which are used to determine the stress state and survival rate after discards must be correctly conducted and interpreted, and therefore require training. Thanks to ILVO research on the use of video and crowdsourcing (product improvement based on the knowledge and skills of
Last updated on: 07-02-2022 - 09:25
Contact: Cannot be disclosed
Organisation: Instituut voor Landbouw-, Visserij- en Voedingsonderzoek (ILVO), NOAA
Status: Published in peer reviewed journal
In the early phases of the design cycle of structural heart devices, choosing which prototype to develop can be complicated. There are a lot of unknowns to contend with. FEops’ simulation technology helps fill in these blanks. It gives product developers computational simulations that let them
Last updated on: 01-02-2022 - 13:17
Contact: Cannot be disclosed
Organisation: FEops
Status: Published in peer reviewed journal
Advances in cell culture methods allowed 3D culture of gut epithelial cells derived from adult intestinal epithelial stem cells in mice and humans. We show that starting from crypts cultured in an extracellular matrix hydrogel together with essential growth factors, gut organoids can be grown from
Last updated on: 20-01-2022 - 16:14
Contact: Bert Devriendt
Organisation: Ghent University (UGent)
Status: Still in development, Published in peer reviewed journal
The cardiorespiratory model reproduces human physiology with a high level of fidelity. It is a lumped parameter model including a representation of atria, ventricles, pulmonary and systemic circulations, autonomic controls, metabolic peripheral control, ventilation and gas exchange in tissues and
Last updated on: 21-10-2021 - 10:07
Contact: Libera Fresiello
Organisation: Cannot be disclosed
Partners: Cannot be disclosed
Status: History of use, Internally validated, Published in peer reviewed journal
Advances in three-dimensional (3D) culture techniques have shown several advantages over 2D cultures, especially by more accurately mimicking the in vivo environment. This has led to improved reproducibility and reliability of experimental results, which are important criteria in disease modelling
Last updated on: 14-10-2021 - 16:59
Contact: Jolanda van Hengel
Organisation: Ghent University (UGent)
Status: Still in development, Published in peer reviewed journal
We aimed to optimize fibrin matrix composition in order to mimic human ovarian tissue architecture for human ovarian follicle encapsulation and grafting. Ultrastructure of fresh human ovarian cortex in age-related women (n = 3) and different fibrin formulations (F12.5/T1, F30/T50, F50/T50, F75/T75),
Last updated on: 10-09-2021 - 14:18
Contact: Christiani Amorim
Organisation: Université Catholique de Louvain (UCL)
Status: Published in peer reviewed journal
