We have established organoids from mouse pituitary with the aim to generate a novel research model to study pituitary stem cell biology in both healthy and diseased glands. The organoids originated from the pituitary cells expressing the stem cell marker SOX2, were long-term expandable, displayed a
Last updated on: 28-01-2021 - 11:08
Contact: Hugo Vankelecom
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
Experiments were conducted using human induced pluripotent stem cells supplemented with hiPSC derived astrocytes and their reagents can be obtained commercially and cultured as per manufacturer’s instructions. One day before plating the cells, each 48-well MEA plate was pre-coated with a
Last updated on: 26-01-2021 - 17:27
Contact: Cannot be disclosed
Organisation: Janssen Pharma of JNJ
Status: Still in development, Published in peer reviewed journal
Experiments were conducted using cortical cells that contains glutamatergic and gabaergic neurons and glia. Primary neurons were freshly dissociated from embryonic E18-19 rat cortices as described previously and plated onto 48-well MEA plates (Maestro system, Axion Biosystems). HOne day before
Last updated on: 26-01-2021 - 17:27
Contact: Cannot be disclosed
Organisation: Janssen Pharma of JNJ
Status: Internally validated, Published in peer reviewed journal
We developed a cellular automata model of oncolytic virotherapy with an application to pancreatic cancer. The fundamental biomedical processes (like cell proliferation, mutation, apoptosis) are modelled by the use of probabilistic principles. The migration of injected viruses (as therapy) is
Last updated on: 07-01-2021 - 21:34
Contact: Fred Vermolen
Organisation: University of Hasselt (UHasselt), Delft University of Technology
Partners: Delft University of Technology, Technion
Status: Published in peer reviewed journal
We developed an innovative model to study the effect of the supernumerary X chromosome on KS features. The model was generated using induced pluripotent stem cells (iPSCs) from patients with Klinefelter syndrome (KS) i.e. with a 47, XXY karyotype. In order to compare the potentials of both 47XXY
Last updated on: 07-01-2021 - 21:23
Contact: Christine Wyns
Organisation: Université Catholique de Louvain (UCL)
Partners: Geneva University Hospitals
Status: Published in peer reviewed journal
We tissue-engineer in vitro, skeletal muscle consisting of aligned myofibers. To create the so-called bio-artificial muscle (BAM), human muscle progenitor cells are expanded, and a 3D construct is created by mixing the cells with a hydrogel. The cell-gel mix is cast into custom-made silicone molds
Last updated on: 08-12-2020 - 17:46
Contact: Lieven Thorrez
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
Characterization of Human Oligodendroglia derived-EV-rich in sHSPs (HOG-EV-sHSPs). Establish HSPB1/B8 stably expressing cell lines for the production of sHSPs rich-EV cell culture conditioned medium. Human Oligodendroglia cell lines (HOG) were stably transduced with pLenti-HSPBs gene constructs
Last updated on: 14-08-2020 - 15:22
Contact: Joy Irobi
Organisation: University of Hasselt (UHasselt)
Status: Still in development, Internally validated, Currently submitted for further validation by an external party (e.g. OECD, EURL ECVAM,…)
Prebiotics are used by the gut microbiota creating metabolites that exert a positive
effect on the host (postbiotics). Prebiotics are available on the market for human and
animal consumption and may induce differential effects on the host's health and
metabolism. They can be tested by in vitro
Last updated on: 16-07-2020 - 15:02
Contact: Nadia Everaert
Organisation: University of Liège (ULiège)
Status: Published in peer reviewed journal
Cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) offer an attractive platform for cardiovascular research, including disease modeling, drug toxicity testing and development of regenerative therapies. Patient-specific iPSC-CMs are very useful to study disease pathogenesis and
Last updated on: 30-06-2020 - 14:13
Contact: Maaike Alaerts
Organisation: University of Antwerp (UAntwerpen)
Status: Still in development, Internally validated
Vascular smooth muscle cell (VSMC) deficiency plays a pivotal role in aneurysm development. Unfortunately, access to native VSMCs of patients and (particularly) control individuals is extremely limited. It has been shown that iPSC-derived VSMCs recapitulate the yet known disease processes very well.
Last updated on: 03-06-2020 - 13:51
Contact: Aline Verstraeten
Organisation: University of Antwerp (UAntwerpen)
Status: Still in development, Internally validated
