The cardiorespiratory model reproduces human physiology with a high level of fidelity. It is a lumped parameter model including a representation of atria, ventricles, pulmonary and systemic circulations, autonomic controls, metabolic peripheral control, ventilation and gas exchange in tissues and

Last updated on: 14-02-2020 - 12:54

Contact: Libera Fresiello
Organisation: Cannot be disclosed
Partners: Cannot be disclosed
Status: History of use, Internally validated, Published in peer reviewed journal

We have developed and validated yeast models to study aspects related to protein folding diseases like Alzheimer's and Parkinson's disease. These models allow to gain further insight in the cellular processes involved in the etiology of these disorders and as such identify potential new bio

Last updated on: 11-02-2020 - 11:17

Contact: Joris Winderickx
Organisation: KU Leuven
Status: Published in peer reviewed journal

The method enables to quantitatively assess the invasion of endothelial cells in extracellular-matrix mimicking hydrogels, such as collagen or polyethylene glycol, and to measure the forces exerted by the cells that enable them to invade. Endothelial cells are seeded on the side of a hydrogel and

Last updated on: 11-02-2020 - 08:55

Organisation: KU Leuven
Status: Published in peer reviewed journal

Patient-derived explants of prostate cancer provide an ex vivo model that retains the architecture and microenvironment of the native tissue. It enables the evaluation of drug responses on individual patient’s tumors ex vivo without passaging in animals. It is compatible with

Last updated on: 07-02-2020 - 15:55

Contact: Johan Swinnen
Organisation: KU Leuven
Partners: University of Adelaide
Status: History of use, Published in peer reviewed journal

Ex vivo lung perfusion (EVLP) is a form of isolated lung perfusion in normothermic conditions and can be achieved with a pump-driven perfusion machine that recirculates a preservation solution through the vasculature of the lung in addition to mechanical ventilation. EVLP is based on a

Last updated on: 07-02-2020 - 15:50

Contact: Arne Neyrinck
Organisation: KU Leuven
Status: Published in peer reviewed journal

The feed undergoes an in vitro enzymatic hydrolysis simulating the digestion in the upper digestive tract followed by a dialysis mimicking the intestinal absorption. Finally, an in vitro batch fermentation is performed and simulates the fermentation occurring in the hindgut. The

Last updated on: 04-02-2020 - 13:36

Contact: Nadia Everaert
Organisation: Liège Université
Status: Published in peer reviewed journal

We have developed an innovative two-chamber skin explant model specifically for studies involving skin of marine fish. An apparatus was 3D-printed and consists of two plates, a lower and upper plate (with funnel). By mounting the explant between the plates, two chambers can be created with the

Last updated on: 04-02-2020 - 13:31

Organisation: Ghent University, Ghent University, Liège Université
Status: Internally validated

The GIDM-colon is a validated in vitro model that allows the study of the availability of compounds and the metabolisation at the level of the colon. The human physiological conditions of the gastrointestinal tract (stomach, small intestine and colon) are mimicked. The continiuous flow

Last updated on: 03-02-2020 - 08:44

Organisation: University of Antwerp
Status: History of use, Internally validated, Published in peer reviewed journal

MELN cells [provided by INSERM, Montpellier, FR; Balaguer et al. (1999)] are oestrogen-sensitive human breast cancer cells (MCF-7) stably transfected with the oestrogen-responsive gene (ERE-βGlo-Luc-SVNeo) carried by integrated plasmids. A standard set-up has been developed to

Last updated on: 28-01-2020 - 16:39

Contact: Cannot be disclosed
Organisation: VITO
Status: History of use, Internally validated, Published in peer reviewed journal

The rainbow trout gill cell line assay quantifies cell viability using fluorescent measurements for metabolic activity (Alamar Blue, AB), cell membrane integrity (5-CarboxyFluorescein DiAcetate AcetoxyMethyl ester, CFDA-AM) and lysosomal membrane integrity (Neutral Red, NR). Chemicals are added

Last updated on: 20-01-2020 - 10:26

Contact: Cannot be disclosed
Organisation: VITO
Status: History of use, Internally validated, Published in peer reviewed journal