This white-box model uses energy partitioning throughout the lifetime of dairy animals (growth, lactation, gestation, ...) to simulate reproduction performance, lifetime length, production performance etc. The method is developed by dr. Olivier Martin at INRAE, MoSAR, Paris.
Last updated on: 04-03-2020 - 14:23
Contact: Cannot be disclosed
Organisation: Cannot be disclosed
Status: History of use, Published in peer reviewed journal
Brain from treated and not treated mice is collected after death. Tissue is fixed in 4% PFA for 4 days. After specific cutting (ex. L and R hemisphere) tissue is placed in a cassette. Cassette is placed in Tissue Processor (where water from the tissue is removed and replaced with paraffin). Brain is
Last updated on: 04-03-2020 - 14:20
Contact: Cannot be disclosed
Organisation: Katholieke Universiteit Leuven (KUL)
Status: History of use, Internally validated
This is a method to study host-microbe interaction in the upper respiratory tract. A physiologically representative epithelial structure, with mucin producing and ciliated cells, is obtained by culturing respiratory epithelial cells at air-liquid interface in Transwell inserts. Optionally,
Last updated on: 28-02-2020 - 10:51
Contact: Charlotte De Rudder
Organisation: Ghent University (UGent)
Status: Still in development, History of use, Internally validated, Published in peer reviewed journal
We have developed and validated yeast models to study aspects related to protein folding diseases like Alzheimer's and Parkinson's disease. These models allow to gain further insight in the cellular processes involved in the etiology of these disorders and as such identify potential new bio-markers
Last updated on: 11-02-2020 - 11:17
Contact: Joris Winderickx
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
Patient-derived explants of prostate cancer provide an ex vivo model that retains the architecture and microenvironment of the native tissue. It enables the evaluation of drug responses on individual patient’s tumors ex vivo without passaging in animals. It is compatible with all molecular analysis
Last updated on: 07-02-2020 - 15:55
Contact: Johan Swinnen
Organisation: Katholieke Universiteit Leuven (KUL)
Partners: University of Adelaide
Status: History of use, Published in peer reviewed journal
Ex vivo lung perfusion (EVLP) is a form of isolated lung perfusion in normothermic conditions and can be achieved with a pump-driven perfusion machine that recirculates a preservation solution through the vasculature of the lung in addition to mechanical ventilation. EVLP is based on a physiological
Last updated on: 07-02-2020 - 15:50
Contact: Arne Neyrinck
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
MELN cells [provided by INSERM, Montpellier, FR; Balaguer et al. (1999)] are oestrogen-sensitive human breast cancer cells (MCF-7) stably transfected with the oestrogen-responsive gene (ERE-βGlo-Luc-SVNeo) carried by integrated plasmids. A standard set-up has been developed to expose MELN cells
Last updated on: 28-01-2020 - 16:39
Contact: Cannot be disclosed
Organisation: Vlaamse Instelling voor Technologisch Onderzoek (VITO)
Status: History of use, Internally validated, Published in peer reviewed journal
The rainbow trout gill cell line assay quantifies cell viability using fluorescent measurements for metabolic activity (Alamar Blue, AB), cell membrane integrity (5-CarboxyFluorescein DiAcetate AcetoxyMethyl ester, CFDA-AM) and lysosomal membrane integrity (Neutral Red, NR). Chemicals are added to
Last updated on: 20-01-2020 - 10:26
Contact: Cannot be disclosed
Organisation: Vlaamse Instelling voor Technologisch Onderzoek (VITO)
Partners: Swiss Federal Institute of Aquatic Science and Technology (EAWAG)
Status: History of use, Internally validated, Published in peer reviewed journal
Identifying drug-target interactions is a crucial step in drug repositioning, the process of suggesting new indications for known drugs. There are about 9000 FDA-approved and experimental small molecule drugs and more than 500.000 protein records available. Performing in vitro experiments would be
Last updated on: 06-01-2020 - 17:04
Contact: Daniele Parisi
Organisation: Katholieke Universiteit Leuven (KUL)
Partners: Biotech/TU-Dresden, Max-Planck-Institut für Informatik Saarbrucken
Status: Still in development
In view of safety of pregnant women, a promising in vitro zebrafish embryo developmental toxicity assay has been developed to test pharmaceutical and chemical compounds for their teratogenic potential. The protocol deals with exposing zebrafish embryos to a range of compound concentrations at 28°C
Last updated on: 06-01-2020 - 16:55
Contact: Steven Van Cruchten
Organisation: University of Antwerp (UAntwerpen)
Status: Still in development, Published in peer reviewed journal
