Humanized yeast models to study aspects related to Alzheimer's and Parkinson's disease
Commonly used acronym: Humanized yeast
Scope of the method
- Human health
- Basic Research
- Education and training
- Translational - Applied Research
- In vitro - Ex vivo
- Other (e.g. bacteria)
- drug testing
- cell death
- protein folding
- protein aggregation
We have developed and validated yeast models to study aspects related to protein folding diseases like Alzheimer's and Parkinson's disease. These models allow to gain further insight in the cellular processes involved in the etiology of these disorders and as such identify potential new bio-markers and targets for therapeutic intervention. These models also offer a screening platform to identify lead compounds, to test the efficacy of drugs or to perform mode-of-action studies.
- Standard yeast culture equipment ;
- Multi-well microplate spectrophotometer/shaker.
- Published in peer reviewed journal
Pros, cons & Future potential
- Proven biological relevant eukaryotic system ;
- Low cost compared to mammalian cell based systems.
Similar yeast based models can be developed for other disease areas, such as cancer.
References, associated documents and other information
Contact personJoris Winderickx