The Systemic Intestinal Fermentation Research technology, SIFR in short, is a uniquely validated simulation of gut microbial ecosystems, shown to be predictive for clinical outcomes. The SIFR can simulate a wide variety of gut microbiota from humans (infants, adults, elderly; healthy, diseased) to
Last updated on: 08-06-2023 - 14:24
Contact: Aurélien Baudot
Organisation: Cryptobiotix
Status: History of use, Internally validated, Published in peer reviewed journal
Using an in vitro flow system adhesion assay, immune cell adhesion to (blood-brain barrier) endothelial cells can be quantified under physiological blood flow conditions. Endothelial cells can be treated with inflammatory cytokines or therapeutic antibodies to mimic inflammatory diseases. Immune
Last updated on: 06-06-2023 - 10:35
Contact: Doryssa Hermans
Organisation: University of Hasselt (UHasselt)
Status: Published in peer reviewed journal
Thyroid hormone system disruption (THSD) has detrimental effects on both human and environmental health. As a rising number of chemicals are reported to interfere with the thyroid hormone system, there is an increasing need for fast and reliable evaluation methods to test for THSD. Currently,
Last updated on: 27-04-2023 - 16:41
Contact: Cannot be disclosed
Organisation: Cannot be disclosed
Partners: Cannot be disclosed
Status: Currently submitted for further validation by an external party (e.g. OECD, EURL ECVAM,…)
Dissolution test aim to evaluate the release profile of a drug from the dosage form. It allows anticipating the potential available dose of the drug within a certain period of time once administered.
Last updated on: 24-04-2023 - 15:34
Contact: Jonathan Goole
Organisation: Université Libre de Bruxelles (ULB)
Status: Published in peer reviewed journal
ProDigest's short-term colonic simulation is an in vitro model for rapid screening of the interaction between test products and the gut microbiome. The key microbial saccharolytic and proteolytic markers are analysed as well as evolution in the composition of the microbiome and other endpoints as
Last updated on: 17-04-2023 - 13:22
Contact: Cannot be disclosed
Organisation: ProDigest
Partners: ProDigest
Status: History of use, Internally validated, Published in peer reviewed journal
Macrophages orchestrate reactive particle segregation, compact aggregates of immune cells and non-immune cells and promote fibrosis-surrounding granulomas.
We developed a simple 3D in-vitro model that mimics granuloma formation and categorizes granuloma-inducing inorganic particles. Macrophage
Last updated on: 03-04-2023 - 11:21
Contact: Léa Hiéronimus
Organisation: Université Catholique de Louvain (UCL)
Status: Still in development, Internally validated
We aim to differentiate ovarian cells isolated from postmenopausal ovaries into steroidogenic theca interna cells. For this purpose, cryopreserved ovarian cortex fragments are used to isolate ovarian cells. These cells are cultured on collagen and supplemented with growth factors defined to promote
Last updated on: 20-03-2023 - 13:52
Contact: Hanne Vlieghe
Organisation: Université Catholique de Louvain (UCL)
Status: Published in peer reviewed journal
Generally, our research group aims to study the influence of food parameters (food design, food processing, food composition) on the digestive kinetics of diverse nutrients throughout the upper gastrointestinal tract. For this, we use in vitro digestion protocols. The current method is a semi
Last updated on: 15-02-2023 - 16:08
Contact: Tara Grauwet
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
Primary epithelial stem/progenitor cell populations are isolated from the murine lung using fluorescence-activated cell sorting (FACS) or magnetic-activated cell sorting (MACS). Purified epithelial stem/progenitor cells are grown together with mesenchymal cells in Matrigel, a material enriched for
Last updated on: 15-02-2023 - 10:50
Contact: Smole Ursula
Organisation: VIB - UGent
Status: Still in development, Published in peer reviewed journal
Computational neuroscience aims to study the nervous system by mathematical and computer simulations. Computational models can be built on multilevel scales. With the bottom-up approach, the model is built from the same building blocks as observed in human or animal tissue. As such, the functioning
Last updated on: 13-02-2023 - 16:45
Contact: Cannot be disclosed
Organisation: Ghent University (UGent)
Status: Still in development, Published in peer reviewed journal
