Alkaptonuria (AKU) is a rare inborn error of metabolism caused by a defective homogentisate 1,2-dioxygenase (HGD), an enzyme involved in the tyrosine degradation pathway. Loss of HGD function leads to the accumulation of homogentisic acid (HGA) in connective body tissues in a process called
Last updated on: 06-12-2023 - 14:45
Contact: Sien Lequeue
Organisation: Vrije Universiteit Brussel (VUB)
Partners: RWTH Aachen
Status: Published in peer reviewed journal
More than 3 million deaths worldwide are linked to excessive alcohol consumption. Alcohol abuse associated gut barrier dysfunction is thought to play an important role in the development of alcohol-associated liver disease. Although some aspects that contribute to this process have been elucidated,
Last updated on: 30-10-2023 - 10:05
Contact: Ami Gloria Toulehohoun
Organisation: Université Catholique de Louvain (UCL)
Partners: UCLouvain, Cliniques universitaires Saint-Luc, UCLouvain
Status: Still in development
The maturation of the human brain shows species-specific differences of neoteny when compared to lower mammals. This process encompass a time window that expands from late embryonic stages to early adolescence. Major features of brain maturation are the acquisition of phenotypic complex traits such
Last updated on: 25-09-2023 - 14:38
Contact: Ira Espuny Camacho
Organisation: University of Liège (ULiège)
Status: Still in development, History of use
The use of patient-derived primary cell cultures in cancer preclinical assays, including drug screens and genotoxic studies, has increased in recent years. However, their translational value is constrained by several limitations, including variability that can be caused by the culture conditions.
Last updated on: 20-07-2023 - 15:05
The Systemic Intestinal Fermentation Research technology, SIFR in short, is a uniquely validated simulation of gut microbial ecosystems, shown to be predictive for clinical outcomes. The SIFR can simulate a wide variety of gut microbiota from humans (infants, adults, elderly; healthy, diseased) to
Last updated on: 08-06-2023 - 14:24
Contact: Aurélien Baudot
Organisation: Cryptobiotix
Status: History of use, Internally validated, Published in peer reviewed journal
Using an in vitro flow system adhesion assay, immune cell adhesion to (blood-brain barrier) endothelial cells can be quantified under physiological blood flow conditions. Endothelial cells can be treated with inflammatory cytokines or therapeutic antibodies to mimic inflammatory diseases. Immune
Last updated on: 06-06-2023 - 10:35
Contact: Doryssa Hermans
Organisation: University of Hasselt (UHasselt)
Status: Published in peer reviewed journal
Macrophages orchestrate reactive particle segregation, compact aggregates of immune cells and non-immune cells and promote fibrosis-surrounding granulomas.
We developed a simple 3D in-vitro model that mimics granuloma formation and categorizes granuloma-inducing inorganic particles. Macrophage
Last updated on: 03-04-2023 - 11:21
Contact: Léa Hiéronimus
Organisation: Université Catholique de Louvain (UCL)
Status: Still in development, Internally validated
Generally, our research group aims to study the influence of food parameters (food design, food processing, food composition) on the digestive kinetics of diverse nutrients throughout the upper gastrointestinal tract. For this, we use in vitro digestion protocols. The current method is a semi
Last updated on: 15-02-2023 - 16:08
Contact: Tara Grauwet
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
We devised a simple and reliable method for reprogramming peripheral blood mononuclear cells into hiPSC and then to differentiate them into air-liquid interface bronchial epithelium (iALI) within 45 days. Of note, this method does not involve any cell sorting step. We reprogrammed blood cells from
Last updated on: 07-02-2023 - 14:46
Contact: Engi Ahmed
Organisation: VIB - UGent, IRMB INSERM 1183
Status: History of use, Internally validated, Published in peer reviewed journal
The purpose of the present development is to use avian MoDCs to implement a cellular platform to increase understanding of the immune responses induced by various antigens of interest (e.g. vaccine candidates) and evaluate their immunogenic potential. Considering the difficulty to work on dendritic
Last updated on: 03-02-2023 - 08:51
