This is a mathematical compartmental formulation of dose-effect synergy modelling for multiple therapies in Non Small Cell Lung Cancer (NSCLC): antiangiogenic, immuno- and radiotherapy. The model formulates the dose-effect relationship in a unified context, with tumor proliferating rates and
Last updated on: 01-02-2021 - 14:32
Contact: Clara Mihaela Ionescu
Organisation: Ghent University (UGent)
Status: Published in peer reviewed journal
We have established organoid cultures from patient-derived ovarian cancer (OC), in particular from the most prevalent high-grade serous ovarian cancer (HGSOC). Testing multiple culture medium components identified neuregulin-1 (NRG1) as key factor in maximizing OC organoid development and growth,
Last updated on: 28-01-2021 - 11:08
Contact: Hugo Vankelecom
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
We have developed multiple organoid models from a broad spectrum of endometrial pathologies that capture endometrial disease diversity and will provide powerful research models and drug screening and discovery tools. Organoids from endometriosis show disease-associated traits and cancer-linked
Last updated on: 28-01-2021 - 11:08
Contact: Hugo Vankelecom
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
We have established organoids from mouse pituitary with the aim to generate a novel research model to study pituitary stem cell biology in both healthy and diseased glands. The organoids originated from the pituitary cells expressing the stem cell marker SOX2, were long-term expandable, displayed a
Last updated on: 28-01-2021 - 11:08
Contact: Hugo Vankelecom
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
Experiments were conducted using human induced pluripotent stem cells supplemented with hiPSC derived astrocytes and their reagents can be obtained commercially and cultured as per manufacturer’s instructions. One day before plating the cells, each 48-well MEA plate was pre-coated with a
Last updated on: 26-01-2021 - 17:27
Contact: Cannot be disclosed
Organisation: Janssen Pharma of JNJ
Status: Still in development, Published in peer reviewed journal
Experiments were conducted using cortical cells that contains glutamatergic and gabaergic neurons and glia. Primary neurons were freshly dissociated from embryonic E18-19 rat cortices as described previously and plated onto 48-well MEA plates (Maestro system, Axion Biosystems). HOne day before
Last updated on: 26-01-2021 - 17:27
Contact: Cannot be disclosed
Organisation: Janssen Pharma of JNJ
Status: Internally validated, Published in peer reviewed journal
We developed a cellular automata model of oncolytic virotherapy with an application to pancreatic cancer. The fundamental biomedical processes (like cell proliferation, mutation, apoptosis) are modelled by the use of probabilistic principles. The migration of injected viruses (as therapy) is
Last updated on: 07-01-2021 - 21:34
Contact: Fred Vermolen
Organisation: University of Hasselt (UHasselt), Delft University of Technology
Partners: Delft University of Technology, Technion
Status: Published in peer reviewed journal
We developed an innovative model to study the effect of the supernumerary X chromosome on KS features. The model was generated using induced pluripotent stem cells (iPSCs) from patients with Klinefelter syndrome (KS) i.e. with a 47, XXY karyotype. In order to compare the potentials of both 47XXY
Last updated on: 07-01-2021 - 21:23
Contact: Christine Wyns
Organisation: Université Catholique de Louvain (UCL)
Partners: Geneva University Hospitals
Status: Published in peer reviewed journal
We tissue-engineer in vitro, skeletal muscle consisting of aligned myofibers. To create the so-called bio-artificial muscle (BAM), human muscle progenitor cells are expanded, and a 3D construct is created by mixing the cells with a hydrogel. The cell-gel mix is cast into custom-made silicone molds
Last updated on: 08-12-2020 - 17:46
Contact: Lieven Thorrez
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
Isolation Femoral and tibial bones are isolated from 10-12 weeks old C57BL/6J mice. After cutting the bone's ends, the bone marrow is flushed out using a 23G syringe with PBS into a 50ml falcon tube. After centrifugation cells are re-suspended in FCS (0.5ml/mouse leg). Differentiation 0.5ml of the
Last updated on: 14-08-2020 - 15:26
Contact: Jerome Hendriks
Organisation: University of Hasselt (UHasselt)
Status: History of use, Internally validated, Published in peer reviewed journal
