Dermatophyte infection of Reconstructed Human Epidermis

Commonly used acronym: RHE

Scope of the method

The Method relates to
  • Human health
The Method is situated in
  • Basic Research
Type of method
  • In vitro - Ex vivo
This method makes use of
  • Human derived cells / tissues / organs
Specify the type of cells/tissues/organs
Human epidermal keratinocytes and Trichophyton rubrum spores

Description

Method keywords
  • Dermatophytes
  • fungal infection
  • tinea
Scientific area keywords
  • dermatology
  • mycology
Method description

The method is about infection of human epidermis in culture by anthropophilic dermatophytes of Trichophyton rubrum species.

Lab equipment

Culture hood, incubators for cell culture, refrigerated centrifuge.

Method status
  • Published in peer reviewed journal

Pros, cons & Future potential

Advantages

Allows ethically acceptable infection of human tissues.

Challenges

Currently, there is no immune cell or adaptative immunity in the model.

References, associated documents and other information

Associated documents
Faway 2016 Med Mycol55-485.pdf
Faway2019-JID139-2080 + suppl.pdf
FawayStaerck2021 jof-07-01029-v2.pdf

Contact person

Yves Poumay

Organisations

Université de Namur (UNamur)
NARILIS
Belgium