Caenorhabditis elegans screening assay in microbiology

Scope of the method

Alternative method relates to
  • Human health
Alternative method is situated in
  • Basic Research
  • Education and training
  • Translational - Applied Research
Type of alternative method
  • In vivo
This method makes use of
  • Animal derived cells / tissues / organs
Used species
Caenorhabditis elegans

Description

Method keywords
  • microbiology
  • infection
  • antibiotics
  • virulence
  • biofilm
Scientific area keywords
  • microbiology
  • antibiotics
  • infection
  • screening
  • virulence
  • biofilm
Method description

The C. elegans assay can be used to study the virulence of various microorganisms, and can be used to evaluate the antimicrobial effect of drugs or drug candidates. The two main outcome parameters are (i) survival of C. elegans and (ii) microbial load.

Lab equipment

Basic microbiology lab equipment.

Method status
  • Published in peer reviewed journal

References, associated documents and other information

Associated documents

Contact person

Tom Coenye

Organisations

Ghent University
Laboratory of Pharmaceutical Microbiology
Belgium