HR MAS analysis of intact tissues consists in the metabolic profiling of entire tumor biopsies using high resolution NMR (nuclear magnetic resonance) using 1H and/or 13C MRS (magnetic resonance spectroscopy). The technique allows combination of metabolomic data with genomic or proteomic data, and
Last updated on: 08-11-2019 - 13:39
Contact: Bénédicte Jordan
Organisation: Université Catholique de Louvain (UCL)
Status: History of use, Published in peer reviewed journal
This method is used to monitor cardiac cell cultures in vitro. It can be used for monitoring both cell activity and drug-induced cardiac side-effects for primary cardiomyocytes or hIPSC-derived cardiomyocytes. Unlike conventional microelectrode array systems that only measure the local field
Last updated on: 08-11-2019 - 13:34
Contact: Thomas Pauwelyn
Organisation: Interuniversitair Micro-Electronica Centrum (IMEC)
Status: Published in peer reviewed journal
Despite major advances in our understanding of neurodegenerative disorders, no efficient therapies are available for patients with dementia, motor neuron disease and other neurodegenerative disorders. With the advent of pluripotent stem cells (PSCs) it now becomes possible to better model human
Last updated on: 08-11-2019 - 13:32
Contact: Cannot be disclosed
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Still in development, Internally validated
We developed in vitro models to study liver disease, such as liver inflammation and fibrosis, as seen in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH); or hepatitis viral infection; or to enhance our ability to detect drugs that cause acute or repeat dose drug induced
Last updated on: 08-11-2019 - 13:32
Contact: Cannot be disclosed
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Internally validated, Published in peer reviewed journal
The chorioallantoic membrane (CAM) is a highly vascularized membrane which results from the fusion of two extra-embryonic membranes, namely the chorion and the allantois. The CAM is easily accessible for manipulation and imaging, but methodologies differ whether the chicken embryo stays within its
Last updated on: 08-11-2019 - 13:27
Better understanding of molecular mechanisms controlling both normal and malignant human hematopoiesis will lead to a more efficient therapy of immune deficiencies and lymphoid leukemias. Therefore, human hematopoietic progenitor cells (HPCs) are differentiated in vitro towards distinct
Last updated on: 08-11-2019 - 13:21
Contact: Tom Taghon
Organisation: Ghent University (UGent)
Status: Internally validated, Published in peer reviewed journal
With a one vessel fermentor (BioFlo 110, New Brunswick), an in vitro simulation of a certain part of the gastrointestinal tract (e.g. cecum, colon) is performed. In this fermentation system, physiological gut parameters (pH, temperature) are kept constant, while chemico-physical characteristics of
Last updated on: 08-11-2019 - 13:20
Contact: Marc Heyndrickx
Organisation: Instituut voor Landbouw-, Visserij- en Voedingsonderzoek (ILVO)
Status: History of use, Internally validated, Published in peer reviewed journal
This method describes the steps from a living mouse to a single cell solution of primary cortical neurons.
Last updated on: 08-11-2019 - 13:17
Contact: Melissa Schepers
Organisation: University of Hasselt (UHasselt)
Status: Internally validated
This method describes the steps from a living mouse to a single cell solution of primary oligodendrocyte precursor cells.
Last updated on: 08-11-2019 - 13:16
Contact: Melissa Schepers
Organisation: University of Hasselt (UHasselt)
Status: Internally validated
This method describes the steps from a living mouse to a multi-cellular brain slice model where complex cellular interactions can be evaluated.
Last updated on: 08-11-2019 - 13:14
Contact: Melissa Schepers
Organisation: University of Hasselt (UHasselt)
Status: Still in development
