We established a human multi-organ-on-chip model to recapitulate key physiological elements of gut-brain communication via the systemic circulation and the blood-cerebrospinal fluid barrier (BCSFB). In our model, a gut-blood barrier, comprised of Caco-2 (enterocytes) and HT29-MTX cells (goblet cells
Last updated on: 18-11-2025 - 13:55
Contact: Debby Laukens
Organisation: Ghent University (UGent), VIB - UGent
Status: Still in development
Primary epithelial stem/progenitor cell populations are isolated from the murine lung using fluorescence-activated cell sorting (FACS) or magnetic-activated cell sorting (MACS). Purified epithelial stem/progenitor cells are grown together with mesenchymal cells in Matrigel, a material enriched for
Last updated on: 15-02-2023 - 10:50
Contact: Smole Ursula
Organisation: VIB - UGent
Status: Still in development, Published in peer reviewed journal
We devised a simple and reliable method for reprogramming peripheral blood mononuclear cells into hiPSC and then to differentiate them into air-liquid interface bronchial epithelium (iALI) within 45 days. Of note, this method does not involve any cell sorting step. We reprogrammed blood cells from
Last updated on: 07-02-2023 - 14:46
Contact: Engi Ahmed
Organisation: VIB - UGent, IRMB INSERM 1183
Status: History of use, Internally validated, Published in peer reviewed journal
