Biomechanical modelling used to simulate functional performance of skeleton and muscle systems in vertebrates. For studying how tissues respond to mechanical loading during movement, we apply finite element modelling. For studying how muscles interact with skeletal elements, and how they make them

Last updated on: 08-11-2019 - 11:05

Organisation: Ghent University
Partners: Hull University
Status: History of use
In the skillslab, dummy models and simulators are used for teaching various clinical skills such as sutures, injections, … The veterinarians in training start with practising basic skills such as handling animals, and progress over the years to perform more complex procedures on simulators such as

Last updated on: 08-11-2019 - 11:02

Organisation: Cannot be disclosed
Status: History of use, Internally validated
The scope of our research ranges from the study of flow and transport processes in blood and biological fluids in the cardiovascular system and artificial organs to biomechanical aspects of the cardiovascular and the skeleto-muscular system and medical devices. All research tracks explored by our

Last updated on: 08-11-2019 - 11:02

Contact: Patrick Segers
Organisation: Ghent University
Functional cardiomyocytes can be efficiently derived from human pluripotent stem cells, which collectively include embryonic and induced pluripotent stem cells (iPSC). Specific affected biological pathways involved in disease can be functionally studied in differentiated cells at a single patient

Last updated on: 08-11-2019 - 11:01

Organisation: Ghent University
Status: Internally validated
The Koken rat is a dummy rat that is developed to train animal procedures, such as handling, blood sampling and intubation.

Last updated on: 08-11-2019 - 10:24

Contact: Cannot be disclosed
Organisation: Cannot be disclosed
The DPRA is an in chemico method which quantifies the remaining concentration of cysteine- or lysine-containing peptide following 24 hours incubation with the test chemical at 25 +/-2,5ºC. The synthetic peptides contain phenylalanine to aid in the detection. Relative peptide concentration is

Last updated on: 08-11-2019 - 10:21

Contact: bart Desmedt
Organisation: Sciensano
Partners: Sciensano
Status: History of use, Internally validated, Validated by an external party (e.g. OECD, EURL ECVAM,…)
The monocyte-activation test (MAT) is used to detect or quantify substances that activate human monocytes or monocytic cells to release endogenous mediators such as pro-inflammatory cytokines, for example tumour necrosis factor alpha (TNFα), interleukin-1 beta (IL-1β) and interleukin-6 (IL-6). These

Last updated on: 08-11-2019 - 10:13

Contact: Celine Vanhee
Organisation: Sciensano
Status: Still in development, History of use
HepG2 is a human hepatoma derived cell line, which are epithelial in morphology. It was established from liver tissue of a 15-year-old Caucasian male with a well differentiated hepatocellular carcinoma. The HepG2 cell line is one of the most used human liver-based in vitro models. The cells secrete

Last updated on: 08-11-2019 - 10:11

Contact: Anja Heymans
Organisation: Vrije Universiteit Brussel
Status: History of use
Human umbilical cord-derived mesenchymal stromal cells (hUC-MSCs) express several key liver-specific transcription factors as well as hepatic progenitor markers. However, they still lack the hepatocyte nuclear factors 1-alpha (HNF1a) and 4-alpha (HNF4a), indispensable for their reprogramming towards

Last updated on: 08-11-2019 - 10:09

Contact: Karolien Buyl
Organisation: Vrije Universiteit Brussel
Status: Still in development