This method is used to monitor cardiac cell cultures in vitro. It can be used for monitoring both cell activity and drug-induced cardiac side-effects for primary cardiomyocytes or hIPSC-derived cardiomyocytes. Unlike conventional microelectrode array systems that only measure the local

Last updated on: 26-08-2019 - 14:16

Contact: Thomas Pauwelyn
Organisation: IMEC
Status: Published in peer reviewed journal

We developed in vitro models to study liver disease, such as liver inflammation and fibrosis, as seen in non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH); or hepatitis viral infection; or to enhance our ability to detect drugs that cause acute or repeat dose

Last updated on: 26-08-2019 - 13:56

Contact: Cannot be disclosed
Organisation: KU Leuven
Status: Internally validated, Published in peer reviewed journal

The chorioallantoic membrane (CAM) is a highly vascularized membrane which results from the fusion of two extra-embryonic membranes, namely the chorion and the allantois. The CAM is easily accessible for manipulation and imaging, but methodologies differ whether the chicken embryo stays within

Last updated on: 23-08-2019 - 10:52

Contact: Hanna Tay
Organisation: Ghent University
Status: Internally validated

Biomechanical modelling used to simulate functional performance of skeleton and muscle systems in vertebrates. For studying how tissues respond to mechanical loading during movement, we apply finite element modelling. For studying how muscles interact with skeletal elements, and how they make

Last updated on: 22-08-2019 - 13:51

Organisation: Ghent University
Partners: Hull University
Status: History of use

Loss of acinar differentiation drives pancreatic cancer. An established human in vitro experimental model is used in our lab to study this process. Pancreatic exocrine cells from human donors are placed in suspension culture in Advanced RPMI medium supplemented with 5% heat-inactivated fetal

Last updated on: 21-08-2019 - 11:36

Contact: Elyne Backx
Organisation: Vrije Universiteit Brussel
Status: Published in peer reviewed journal

The lab routinely use C. elegans culture as genetic model. We explore the development and the ageing of the neuromuscular system. The methods used regularly in our lab include molecular biology, generation of transgenic animals or mutants, crossings, genetic screen, calcium imaging, fluorescence

Last updated on: 25-07-2019 - 13:36

Contact: patrick laurent
Organisation: ULB
Status: Internally validated, Published in peer reviewed journal

In the skillslab, dummy models and simulators are used for teaching various clinical skills such as sutures, injections, … The veterinarians in training start with practising basic skills such as handling animals, and progress over the years to perform more complex procedures on simulators such

Last updated on: 17-07-2019 - 14:53

Organisation: Cannot be disclosed
Status: History of use, Internally validated

Functional cardiomyocytes can be efficiently derived from human pluripotent stem cells, which collectively include embryonic and induced pluripotent stem cells (iPSC). Specific affected biological pathways involved in disease can be functionally studied in differentiated cells at a single patient

Last updated on: 12-07-2019 - 16:55

Organisation: Ghent University
Status: Internally validated