The application of liver organoids is very promising in the field of liver tissue engineering; however, it is still facing some limitations. One of the current major limitations is the matrix in which they are cultured. The mainly undefined and murine-originated tumor matrices derived from

Last updated on: 22-01-2024 - 17:28

Organisation: Ghent University (UGent)
Status: Published in peer reviewed journal
The culture of primary human synoviocytes provides an excellent cellular model for studying the normal and pathological physiology of synoviocytes and the development of joint diseases. Human primary synoviocytes can either be provided by commercial suppliers or isolated from fresh biological

Last updated on: 17-01-2024 - 11:32

Contact: Julie Uerlings
Organisation: ARTIALIS
Status: History of use, Internally validated
Adverse outcome pathway (AOP) networks are versatile tools in toxicology and risk assessment that capture and visualize mechanisms driving toxicity originating from various data sources. They share a common structure consisting of a set of molecular initiating events and key events, connected by key

Last updated on: 20-02-2024 - 09:27

Contact: Cannot be disclosed
Organisation: Vrije Universiteit Brussel (VUB)
Status: Published in peer reviewed journal
Method to culture human epidermal keratinocytes and seed them for tissue reconstruction at the air-liquid interface over a polycarbonate porous membrane.

Last updated on: 19-12-2023 - 19:19

Contact: Yves Poumay
Organisation: Université de Namur (UNamur)
Status: Published in peer reviewed journal
More than 3 million deaths worldwide are linked to excessive alcohol consumption. Alcohol abuse associated gut barrier dysfunction is thought to play an important role in the development of alcohol-associated liver disease. Although some aspects that contribute to this process have been elucidated,

Last updated on: 30-10-2023 - 10:05

Organisation: Université Catholique de Louvain (UCL)
Partners: UCLouvain, Cliniques universitaires Saint-Luc, UCLouvain
Status: Still in development
Fiber biopersistence is a key factor in understanding the pathogenicity of man-made vitreous fibres (MMVF). Today, compliance to Note Q in Annex VI of Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures may only be demonstrated via in vivo

Last updated on: 19-12-2023 - 19:17

Contact: Léa Hiéronimus
Organisation: Eurima is the European Insulation Manufacturers Association
Status: Still in development, Internally validated, Published in peer reviewed journal
Endotoxins are lipopolysaccharides anchored at the outer membrane of gram-negative bacteria. These pyrogenic compounds can be introduced in pharmaceutical products during their manufacture and could induce severe physiological reactions in humans. This is why endotoxins are dosed, in order to assure

Last updated on: 28-09-2023 - 11:59

Contact: Flore Laurent
Organisation: Sciensano
Status: Internally validated, Validated by an external party (e.g. OECD, EURL ECVAM,…)
The maturation of the human brain shows species-specific differences of neoteny when compared to lower mammals. This process encompass a time window that expands from late embryonic stages to early adolescence. Major features of brain maturation are the acquisition of phenotypic complex traits such

Last updated on: 25-09-2023 - 14:38

Organisation: University of Liège (ULiège)
Status: Still in development, History of use
Immersion treatment: zebrafish embryos at the two-cell stage were immersed in Danieau’s medium containing the compound. A compound concentration of 10 µM and DMSO concentration of 0.1% (v/v) in a volume of 5 mL was used per well (6-well-plates). At 72 h, the zebrafish medium containing the compound

Last updated on: 01-09-2023 - 09:32

Contact: Marie Pardon
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal