The lab routinely use C. elegans culture as genetic model. We explore the development and the ageing of the neuromuscular system. The methods used regularly in our lab include molecular biology, generation of transgenic animals or mutants, crossings, genetic screen, calcium imaging, fluorescence

Last updated on: 12-11-2019 - 17:36

Contact: patrick laurent
Organisation: Université libre de Bruxelles
Status: Internally validated, Published in peer reviewed journal

FIBEr (Flanders Institute for Biomechanical Experimentation) is a laboratory that investigates the mechanical properties (stiffness, strength, microstructure) of biological tissue, in casu bones, muscles, ligaments, blood vessels, etc. A quantitative characterization of the mechanical behavior of

Last updated on: 12-11-2019 - 11:45

Contact: Nele Famaey
Organisation: KU Leuven, KU Leuven
Partners: KU Leuven, KU Leuven , KU Leuven , KU Leuven
Status: Still in development, History of use, Internally validated

Integrated approach for the characterization,validation and monitoring of protein biomarkers in animal tissue samples as well as on human tissue samples. The ''cell-block'' technique allows the study of cell lines with the same approach. The methodology involves histological and standardized

Last updated on: 12-11-2019 - 11:37

Contact: Cédric Balsat
Organisation: Université libre de Bruxelles
Partners: ULB, ULB
Status: Published in peer reviewed journal

Epigenetics have taken centre stage in the study of diseases such as cancer, diabetes, and neurodegeneration. A new field is emerging that targets epigenetic modifications for therapeutic intervention: pharmacoepigenetics. Particularly in oncology, inhibitors of epigenetic-modifying proteins, i.e

Last updated on: 12-11-2019 - 11:34

Contact: Maarten Dhaenens
Organisation: Ghent University
Status: Still in development, Internally validated, Published in peer reviewed journal

It is the goal of the DNA-adductomics to search for DNA-adducts that might be formed during interaction with contaminants. The analysis of DNA adducts is performed using ultra-high performance liquid chromatography coupled to hybrid quadrupole-Orbitrap high resolution mass spectrometry. Both the

Last updated on: 12-11-2019 - 11:16

Contact: Lynn Vanhaecke
Organisation: Ghent University
Status: Internally validated, Published in peer reviewed journal

Our polar metabolomics profiling and fingerprinting methodology applies ultra-high performance liquid chromatography coupled to hybrid quadrupole-Orbitrap high resolution mass spectrometry. Both the instrumental method, as well as generic extraction protocols for colon tissue, cell cultures,

Last updated on: 12-11-2019 - 11:13

Contact: Lynn Vanhaecke
Organisation: Ghent University
Status: Internally validated, Published in peer reviewed journal

The aim of these in vitro digestions is to simulate the gastrointestinal digestion of specific food sources and to identify metabolites that might be formed out of this food source by the residing microbiome. For this purpose, fecal samples will be collected from volunteers and will be

Last updated on: 12-11-2019 - 10:56

Contact: Lynn Vanhaecke
Organisation: Ghent University
Status: Published in peer reviewed journal

Our lipidomics profiling and fingerprinting methodology enables the analysis of all lipids within a biological matrix. These lipids can then be compared between an individual or condition with a specific metabolic state and healthy controls to find biomarkers or pathways that can be related to

Last updated on: 08-11-2019 - 14:12

Contact: Lynn Vanhaecke
Organisation: Ghent University
Status: History of use, Internally validated, Published in peer reviewed journal

Aortic aneurysms consist of a localized dilatation of the aorta resulting from compromised structural integrity and are characterized by a diameter increase of at least 50% compared to a reference diameter. When left untreated, aneurysms tend to progressively enlarge, with an increased risk of

Last updated on: 08-11-2019 - 14:11

Contact: Nele Famaey
Organisation: KU Leuven, KU Leuven
Partners: KU Leuven, KU Leuven , KU Leuven
Status: Still in development, Published in peer reviewed journal