This is a mathematical compartmental formulation of dose-effect synergy modelling for multiple therapies in Non Small Cell Lung Cancer (NSCLC): antiangiogenic, immuno- and radiotherapy. The model formulates the dose-effect relationship in a unified context, with tumor proliferating rates and
Last updated on: 01-02-2021 - 14:32
Contact: Clara Mihaela Ionescu
Organisation: Ghent University (UGent)
Status: Published in peer reviewed journal
Computational Fluid Dynamics (CFD) is being applied to characterize the fluid flow in different applications. CFD has obtained significant interest in both the medical and engineering community because of its non-invasive character. It can predict the fluid flow characteristics when one or multiple
Last updated on: 10-04-2020 - 09:22
Contact: Mohammad Rahimi Gorji
Organisation: Ghent University (UGent)
Status: Still in development, Published in peer reviewed journal
Retinal gene delivery via intravitreal injection is hampered by various physiological barriers present in the eye of which the vitreoretinal (VR) interface represents the most serious hurdle. We present a retinal explant model especially designed to study the role of this interface as a barrier for
Last updated on: 24-03-2020 - 16:26
Contact: Katrien Remaut
Organisation: Ghent University (UGent)
Status: Published in peer reviewed journal
Mononuclear cells are flushed from the bone marrow using a 25G needle. After centrifugation, the cells are resuspended in 50mL pre-heated DMEM containing 20ng/ml M-CSF. The cells are cultured in 10cm petri dishes for 7 days. At days 2,4 and 6, the medium is renewed after washing away non-adherent
Last updated on: 10-03-2020 - 10:17
Contact: Cannot be disclosed
Organisation: Ghent University (UGent)
Partners: Ghent University hospital (UZ Gent)
Status: Published in peer reviewed journal
This is a method to study host-microbe interaction in the upper respiratory tract. A physiologically representative epithelial structure, with mucin producing and ciliated cells, is obtained by culturing respiratory epithelial cells at air-liquid interface in Transwell inserts. Optionally,
Last updated on: 28-02-2020 - 10:51
Contact: Charlotte De Rudder
Organisation: Ghent University (UGent)
Status: Still in development, History of use, Internally validated, Published in peer reviewed journal
We have developed an innovative two-chamber skin explant model specifically for studies involving skin of marine fish. An apparatus was 3D-printed and consists of two plates, a lower and upper plate (with funnel). By mounting the explant between the plates, two chambers can be created with the
Last updated on: 04-02-2020 - 13:31
Contact: Maaike Vercauteren
Organisation: Ghent University (UGent), University of Liège (ULiège)
Status: Internally validated
We describe a fluorescent cell-based in vitro infection model that reproduces host-Batrachochytrium dendrobatidis (Bd) interactions. Using the epithelial cell line A6 from Xenopus laevis, we reproduced different stages of host cell infection and intracellular growth of Bd, resulting in host cell
Last updated on: 10-01-2020 - 15:28
Contact: Elin Verbrugghe
Organisation: Ghent University (UGent)
Status: Published in peer reviewed journal
The BALB/c-derived - 4T1 mammary tumor cell line and RAW264.7 macrophage cell line were maintained in Dulbecco’s Modified Eagle’s Medium (DMEM) supplemented with 10% heat-inactivated fetal bovine serum (FBS), 100 U/ml penicillin and 100 μg/ml streptomycin in culture flasks. Harvesting of cultured
Last updated on: 26-11-2019 - 13:12
Contact: Kristel Demeyere
Organisation: Ghent University (UGent)
Status: Published in peer reviewed journal
This silicone rat is designed for training persons to perform oral gavage of fluids and for learning how to perform blood sampling from the lateral tail vein.
Last updated on: 13-11-2019 - 09:22
Epigenetics have taken centre stage in the study of diseases such as cancer, diabetes, and neurodegeneration. A new field is emerging that targets epigenetic modifications for therapeutic intervention: pharmacoepigenetics. Particularly in oncology, inhibitors of epigenetic-modifying proteins, i.e.
Last updated on: 12-11-2019 - 11:34
Contact: Maarten Dhaenens
Organisation: Ghent University (UGent)
Status: Still in development, Internally validated, Published in peer reviewed journal
