In silico model relates toll-like receptor 4 (TLR4) trafficking to sepsis progression
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection and a major public health concern, particularly for the very young and very old. Around the world, sepsis kills more people than AIDS, breast cancer and prostate cancer combined.
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In an attempt to gain some much-needed insights into sepsis progression in humans and to enable more accurate predictions of patient outcome, de Camargo and colleagues, researchers from the Institute of Biomedical Sciences at the University of São Paulo, have developed an A mathematical model that relates intracellular TLR4 (toll-like receptor 4) oscillations to sepsis progression
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Source: BioMed21
