Immersion treatment: zebrafish embryos at the two-cell stage were immersed in Danieau’s medium containing the compound. A compound concentration of 10 µM and DMSO concentration of 0.1% (v/v) in a volume of 5 mL was used per well (6-well-plates). At 72 h, the zebrafish medium containing the compound
Last updated on: 01-09-2023 - 09:32
Contact: Marie Pardon
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
NMTox is an R-software package and a Shiny app that can be used to explore and subset large datasets and can identify and test for monotonic dose responses. The package was developed within the NanoInformaTIX project where a platform is developed that aims to predict nanomaterial toxicity.
Last updated on: 22-08-2023 - 10:43
Contact: Geert Verheyen
Organisation: Thomas More University of Applied Sciences, University of Hasselt (UHasselt)
Status: Internally validated
The use of patient-derived primary cell cultures in cancer preclinical assays, including drug screens and genotoxic studies, has increased in recent years. However, their translational value is constrained by several limitations, including variability that can be caused by the culture conditions.
Last updated on: 20-07-2023 - 15:05
The Systemic Intestinal Fermentation Research technology, SIFR in short, is a uniquely validated simulation of gut microbial ecosystems, shown to be predictive for clinical outcomes. The SIFR can simulate a wide variety of gut microbiota from humans (infants, adults, elderly; healthy, diseased) to
Last updated on: 08-06-2023 - 14:24
Contact: Aurélien Baudot
Organisation: Cryptobiotix
Status: History of use, Internally validated, Published in peer reviewed journal
Using an in vitro flow system adhesion assay, immune cell adhesion to (blood-brain barrier) endothelial cells can be quantified under physiological blood flow conditions. Endothelial cells can be treated with inflammatory cytokines or therapeutic antibodies to mimic inflammatory diseases. Immune
Last updated on: 06-06-2023 - 10:35
Contact: Doryssa Hermans
Organisation: University of Hasselt (UHasselt)
Status: Published in peer reviewed journal
Thyroid hormone system disruption (THSD) has detrimental effects on both human and environmental health. As a rising number of chemicals are reported to interfere with the thyroid hormone system, there is an increasing need for fast and reliable evaluation methods to test for THSD. Currently,
Last updated on: 27-04-2023 - 16:41
Contact: Cannot be disclosed
Organisation: Cannot be disclosed
Partners: Cannot be disclosed
Status: Currently submitted for further validation by an external party (e.g. OECD, EURL ECVAM,…)
ZeptoHit is a technology based on Artificial Intelligence (AI) which accelerates hit discovery. With only a protein sequence as information, ZeptoHit can quickly and efficiently recommend promising hits, without any limitations. Its search for promising compounds goes much beyond chemical structures
Last updated on: 21-03-2023 - 13:36
Contact: Segolene Martin
Organisation: Kantify
Status: Internally validated, Published in peer reviewed journal
ZeptoWard is a Machine Learning solution (AI) which identifies the ADMET properties of compounds. It can accurately predict over 80 properties related to absorption, distribution, metabolism, excretion, and toxicity properties, how a specific compound or combination of compounds will perform. It can
Last updated on: 21-03-2023 - 13:34
Generally, our research group aims to study the influence of food parameters (food design, food processing, food composition) on the digestive kinetics of diverse nutrients throughout the upper gastrointestinal tract. For this, we use in vitro digestion protocols. The current method is a semi
Last updated on: 15-02-2023 - 16:08
Contact: Tara Grauwet
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
Full-wave electromagnetic (EM) simulations solve the laws of Maxwell for a given problem. When designing a wireless solution for an Internet of Animal Health (IoAH) application, multiple iterations are needed to achieve well-defined metrics such as energy efficiency, electrical and mechanical
Last updated on: 13-02-2023 - 16:48
Contact: Jasper Goethals
Organisation: Ghent University (UGent)
Partners: Ghent University (UGent)
Status: Internally validated
