Transport kinetics accross the skin and/or mucosa is investigated using Franz diffusion cells and LC-UV/MS detection of the investigated molecule in the receptor compartment.

Last updated on: 08-11-2019 - 14:05

Contact: Yorick Janssens
Organisation: Ghent University
Status: Internally validated, Published in peer reviewed journal

This work will be based on data describing the rat hindlimb kinematics obtained by X-Ray Reconstruction of Moving Morphology (XROMM) and ground reaction forces following destabilization of the medial meniscus (DMM) and running. These data will be analyzed with multi-body dynamics to estimate the

Last updated on: 08-11-2019 - 14:02

Contact: Judith Piet
Organisation: KU Leuven
Status: Still in development

A compound of interest (e.g. new psychoactive substance, endocrine disrupting compound, ...) is incubated with human liver microsomes and liver cytosolic fractions to generate both Phase I and II metabolites. Samples are prepared for analysis using a simple method in order to avoid possible

Last updated on: 08-11-2019 - 14:01

Organisation: University of Antwerp
Status: Published in peer reviewed journal

Follicle Biology Laboratory has developed a well characterized and standardized MOUSE in vitro follicle culture (IFC) system. In this system, early stage ovarian follicles are cultured in vitro under physiological hormone concentrations up to fertilizable and developmentally

Last updated on: 08-11-2019 - 14:00

Contact: Ellen Anckaert
Organisation: Vrije Universiteit Brussel
Status: History of use, Internally validated, Published in peer reviewed journal

Three-dimensional (3D) lung epithelial cell models mimic key aspects of the parental tissue, including apical-basolateral polarity and barrier function (Barrila et al. 2010, PMID: 20948552). These 3D cultures are generated using the rotating wall vessel (RWV) bioreactor system, allowing host

Last updated on: 08-11-2019 - 13:59

Contact: Aurélie Crabbé
Organisation: Ghent University
Status: Published in peer reviewed journal

The Galleria mellonella assay makes use of larvae of the Greater Wax Moth. G. mellonella larvae are injected with a small amount of microorganisms, and survival can easily be followed for up to 1 week. This allows to compare virulence between different organisms. Alternatively,

Last updated on: 08-11-2019 - 13:58

Contact: Tom Coenye
Organisation: Ghent University
Status: Published in peer reviewed journal

The C. elegans assay can be used to study the virulence of various microorganisms, and can be used to evaluate the antimicrobial effect of drugs or drug candidates. The two main outcome parameters are (i) survival of C. elegans and (ii) microbial load.

Last updated on: 08-11-2019 - 13:57

Contact: Tom Coenye
Organisation: Ghent University
Status: Published in peer reviewed journal

ProDigest's short-term colonic simulation is an in vitro model for rapid screening of the interaction between test products and the gut microbiome. The key microbial saccharolytic and proteolytic markers are analysed as well as evolution in the composition of the microbiome and other

Last updated on: 08-11-2019 - 13:57

Contact: Aurélien Baudot
Organisation: ProDigest
Partners: ProDigest, ProDigest
Status: History of use, Internally validated, Published in peer reviewed journal

Hyper Polarized (HP) MR allows to considerably increase the sensitivity (>10.000) of MR spectroscopy and spectroscopic imaging. The hyperpolarized molecule can be injected at room temperature to a cell system or an in vivo model and its metabolism can be followed over a few minutes

Last updated on: 08-11-2019 - 13:56

Organisation: UCLouvain
Status: Published in peer reviewed journal