Through leveraging our combined computational and biological knowledge, we have proven expertise supporting clients in:
(1) Evaluating and validating the potential for predictive modeling within your projects,
(2) Developing and applying machine learning techniques and other AI-based
Last updated on: 11-03-2024 - 13:31
Contact: Cannot be disclosed
Organisation: BioLizard
Status: History of use, Internally validated, Validated by an external party (e.g. OECD, EURL ECVAM,…)
Through leveraging our combined computational and biological knowledge, we have proven expertise supporting clients in:
(1) Developing and applying a range of statistical methods tailored to specific problem settings in both clinical and non-clinical datasets,
(2) Integrating multi-omics
Last updated on: 11-03-2024 - 13:30
Contact: Cannot be disclosed
Organisation: BioLizard
Status: History of use, Internally validated, Published in peer reviewed journal, Validated by an external party (e.g. OECD, EURL ECVAM,…)
Adult intestinal stem cells are grown into closed 3D structures with protruding buds and a luminal compartment. These 3D structures are produced from the stem cells present in the base of crypts isolated from rectal mucosa samples that can be collected by suction or forceps biopsy. The crypts are
Last updated on: 22-02-2024 - 11:15
Contact: Anabela Ramalho
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
Drug-induced phospholipidosis (DIPL) is a metabolic disorder characterized by an excessive intracellular accumulation of phospholipids caused by cationic drugs. Hepatic cells derived from human skin are evaluated as an in vitro model to investigate DIPL and its mechanisms. Human skin stem cells
Last updated on: 20-02-2024 - 11:27
Contact: Cannot be disclosed
Organisation: Vrije Universiteit Brussel (VUB)
Status: History of use
Adverse outcome pathway (AOP) networks are versatile tools in toxicology and risk assessment that capture and visualize mechanisms driving toxicity originating from various data sources. They share a common structure consisting of a set of molecular initiating events and key events, connected by key
Last updated on: 20-02-2024 - 09:27
Contact: Cannot be disclosed
Organisation: Vrije Universiteit Brussel (VUB)
Status: Published in peer reviewed journal
Drug-induced intrahepatic cholestasis (DIC) is a main type of hepatic toxicity that is challenging to predict in early drug development stages. Preclinical animal studies often fail to detect DIC in humans. In vitro toxicogenomics assays using human liver cells have become a practical approach to
Last updated on: 15-02-2024 - 11:59
Contact: Cannot be disclosed
Organisation: Vrije Universiteit Brussel (VUB)
Status: Internally validated, Published in peer reviewed journal
The chick chorioallantoic membrane (CAM) model is particularly attractive to study short-term xenografting of human ovarian tissue. Its angiogenic potential and natural immunodeficiency allow scrutiny of early follicle activation and loss and graft revascularization mechanisms. Chick embryo
Last updated on: 14-02-2024 - 17:24
Contact: Luciana Cacciottola
Organisation: Université Catholique de Louvain (UCL)
Status: Internally validated, Published in peer reviewed journal
The culture of primary human synoviocytes provides an excellent cellular model for studying the normal and pathological physiology of synoviocytes and the development of joint diseases. Human primary synoviocytes can either be provided by commercial suppliers or isolated from fresh biological
Last updated on: 17-01-2024 - 11:32
Alkaptonuria (AKU) is a rare inborn error of metabolism caused by a defective homogentisate 1,2-dioxygenase (HGD), an enzyme involved in the tyrosine degradation pathway. Loss of HGD function leads to the accumulation of homogentisic acid (HGA) in connective body tissues in a process called
Last updated on: 06-12-2023 - 14:45
Contact: Sien Lequeue
Organisation: Vrije Universiteit Brussel (VUB)
Partners: RWTH Aachen
Status: Published in peer reviewed journal
More than 3 million deaths worldwide are linked to excessive alcohol consumption. Alcohol abuse associated gut barrier dysfunction is thought to play an important role in the development of alcohol-associated liver disease. Although some aspects that contribute to this process have been elucidated,
Last updated on: 30-10-2023 - 10:05
Contact: Ami Gloria Toulehohoun
Organisation: Université Catholique de Louvain (UCL)
Partners: UCLouvain, Cliniques universitaires Saint-Luc, UCLouvain
Status: Still in development