Alkaline comet assay (COM) and Micronucleus test (MN) are well-established cytogenetic tests that are used to detect both immediate damages i.e. DNA fragmentation, and permanent damage which results in micronuclei formation. These techniques are often applied separately or, sometimes, in combination

Fever-inducing substances need to be traced in medical packaging material. To do so, in the past, rabbits were often exposed to these substances. Causing enormous amounts of animal suffering. Nowadays this test has been largely replaced by the so-called LAL (Limulus amebocyte lysate) test, which