The Colon-on-a-plate® technology is a high-throughput biorelevant in vitro simulation of the physiology and microbiology of the colon. This robust screening technology is not limited to comparing the impact of tens of test product on the microbiome, but also offers insight into the factors
Last updated on: 26-07-2024 - 09:50
Contact: Cannot be disclosed
Organisation: ProDigest
Status: History of use, Internally validated, Published in peer reviewed journal
The SHIME® (Simulator of Human Intestinal Microbial Ecosystem) model is currently the most representative in vitro technology for the combined simulation of the physiological, chemical and microbiological properties of the gastrointestinal tract. The model enables study of the impact of long-term
Last updated on: 26-07-2024 - 09:49
Contact: Cannot be disclosed
Organisation: ProDigest
Status: History of use, Internally validated, Published in peer reviewed journal
The maturation of the human brain shows species-specific differences of neoteny when compared to lower mammals. This process encompass a time window that expands from late embryonic stages to early adolescence. Major features of brain maturation are the acquisition of phenotypic complex traits such
Last updated on: 25-09-2023 - 14:38
Contact: Ira Espuny Camacho
Organisation: University of Liège (ULiège)
Status: Still in development, History of use
An empirical model linking physico-chemical biomaterial characteristics to intra-oral bone formation
This empirical model is used to assess the weighted value of driving biomaterials properties in the intra-oral bone regeneration process. We used partial least square regression (PLSR) to construct empirical models that relate combinations of (quantified) biomaterial characteristics to intra-oral
Last updated on: 08-06-2023 - 14:26
Contact: Ehsan Sadeghian
Organisation: University of Liège (ULiège)
Partners: Katholieke Universiteit Leuven (KUL), University of Liège (ULiège), Université Catholique de Louvain (UCL)
Status: Internally validated
ProDigest's short-term colonic simulation is an in vitro model for rapid screening of the interaction between test products and the gut microbiome. The key microbial saccharolytic and proteolytic markers are analysed as well as evolution in the composition of the microbiome and other endpoints as
Last updated on: 17-04-2023 - 13:22
Contact: Cannot be disclosed
Organisation: ProDigest
Partners: ProDigest
Status: History of use, Internally validated, Published in peer reviewed journal
The feed undergoes an in vitro enzymatic hydrolysis simulating the digestion in the upper digestive tract followed by a dialysis mimicking the intestinal absorption. Finally, an in vitro batch fermentation is performed and simulates the fermentation occurring in the hindgut. The ingredients, ground
Last updated on: 16-07-2020 - 15:04
Contact: Nadia Everaert
Organisation: University of Liège (ULiège)
Status: Published in peer reviewed journal
Prebiotics are used by the gut microbiota creating metabolites that exert a positive
effect on the host (postbiotics). Prebiotics are available on the market for human and
animal consumption and may induce differential effects on the host's health and
metabolism. They can be tested by in vitro
Last updated on: 16-07-2020 - 15:02
Contact: Nadia Everaert
Organisation: University of Liège (ULiège)
Status: Published in peer reviewed journal
We have developed an innovative two-chamber skin explant model specifically for studies involving skin of marine fish. An apparatus was 3D-printed and consists of two plates, a lower and upper plate (with funnel). By mounting the explant between the plates, two chambers can be created with the
Last updated on: 04-02-2020 - 13:31
Contact: Maaike Vercauteren
Organisation: Ghent University (UGent), University of Liège (ULiège)
Status: Internally validated