Organotypical culture models, such as retinal explants, is an ideal alternative for in vitro retinal cell cultures and preclinical animal models, as they provide the necessary compromise between these two model systems. The major advantage of explant cultures is that cells are kept

Last updated on: 21-02-2020 - 14:51

Contact: Evy Lefevere
Organisation: KU Leuven
Status: Internally validated, Published in peer reviewed journal

The cardiorespiratory model reproduces human physiology with a high level of fidelity. It is a lumped parameter model including a representation of atria, ventricles, pulmonary and systemic circulations, autonomic controls, metabolic peripheral control, ventilation and gas exchange in tissues and

Last updated on: 14-02-2020 - 12:54

Contact: Libera Fresiello
Organisation: Cannot be disclosed
Partners: Cannot be disclosed
Status: History of use, Internally validated, Published in peer reviewed journal

We have developed and validated yeast models to study aspects related to protein folding diseases like Alzheimer's and Parkinson's disease. These models allow to gain further insight in the cellular processes involved in the etiology of these disorders and as such identify potential new bio

Last updated on: 11-02-2020 - 11:17

Contact: Joris Winderickx
Organisation: KU Leuven
Status: Published in peer reviewed journal

The method enables to quantitatively assess the invasion of endothelial cells in extracellular-matrix mimicking hydrogels, such as collagen or polyethylene glycol, and to measure the forces exerted by the cells that enable them to invade. Endothelial cells are seeded on the side of a hydrogel and

Last updated on: 11-02-2020 - 08:55

Organisation: KU Leuven
Status: Published in peer reviewed journal

Patient-derived explants of prostate cancer provide an ex vivo model that retains the architecture and microenvironment of the native tissue. It enables the evaluation of drug responses on individual patient’s tumors ex vivo without passaging in animals. It is compatible with

Last updated on: 07-02-2020 - 15:55

Contact: Johan Swinnen
Organisation: KU Leuven
Partners: University of Adelaide
Status: History of use, Published in peer reviewed journal

Ex vivo lung perfusion (EVLP) is a form of isolated lung perfusion in normothermic conditions and can be achieved with a pump-driven perfusion machine that recirculates a preservation solution through the vasculature of the lung in addition to mechanical ventilation. EVLP is based on a

Last updated on: 07-02-2020 - 15:50

Contact: Arne Neyrinck
Organisation: KU Leuven
Status: Published in peer reviewed journal

We have successfully set-up the iPSC technology and are able to derive human cortical neurons for the study of neurodevelopmental disorders e.g. the MECP2 duplication syndrome (published) and other projects in the lab (ongoing). We also create isogenic lines using CrispR-Cas technology. All lines

Last updated on: 07-01-2020 - 15:23

Contact: Hilde Van Esch
Organisation: KU Leuven
Status: Still in development, History of use, Published in peer reviewed journal

Identifying drug-target interactions is a crucial step in drug repositioning, the process of suggesting new indications for known drugs. There are about 9000 FDA-approved and experimental small molecule drugs and more than 500.000 protein records available. Performing in vitro

Last updated on: 06-01-2020 - 17:04

Contact: Daniele Parisi
Organisation: KU Leuven
Partners: Biotech/TU-Dresden, Max-Planck-Institut für Informatik Saarbrucken
Status: Still in development

FIBEr (Flanders Institute for Biomechanical Experimentation) is a laboratory that investigates the mechanical properties (stiffness, strength, microstructure) of biological tissue, in casu bones, muscles, ligaments, blood vessels, etc. A quantitative characterization of the mechanical behavior of

Last updated on: 12-11-2019 - 11:45

Contact: Nele Famaey
Organisation: KU Leuven, KU Leuven
Partners: KU Leuven, KU Leuven , KU Leuven , KU Leuven
Status: Still in development, History of use, Internally validated

Aortic aneurysms consist of a localized dilatation of the aorta resulting from compromised structural integrity and are characterized by a diameter increase of at least 50% compared to a reference diameter. When left untreated, aneurysms tend to progressively enlarge, with an increased risk of

Last updated on: 08-11-2019 - 14:11

Contact: Nele Famaey
Organisation: KU Leuven, KU Leuven
Partners: KU Leuven, KU Leuven , KU Leuven
Status: Still in development, Published in peer reviewed journal