The GIDM-colon is a validated in vitro model that allows the study of the availability of compounds and the metabolisation at the level of the colon. The human physiological conditions of the gastrointestinal tract (stomach, small intestine and colon) are mimicked. The continiuous flow

Last updated on: 03-02-2020 - 08:44

Organisation: University of Antwerp
Status: History of use, Internally validated, Published in peer reviewed journal

In view of safety of pregnant women, a promising in vitro zebrafish embryo developmental toxicity assay has been developed to test pharmaceutical and chemical compounds for their teratogenic potential. The protocol deals with exposing zebrafish embryos to a range of compound

Last updated on: 06-01-2020 - 16:55

Organisation: University of Antwerp
Status: Still in development, Published in peer reviewed journal

A compound of interest (e.g. new psychoactive substance, endocrine disrupting compound, ...) is incubated with human liver microsomes and liver cytosolic fractions to generate both Phase I and II metabolites. Samples are prepared for analysis using a simple method in order to avoid possible

Last updated on: 08-11-2019 - 14:01

Organisation: University of Antwerp
Status: Published in peer reviewed journal