We have implemented the use of 3D patient-derived tumor organoids, to study metabolic (dys)functions associated with tumor development and progression, including response to anticancer therapies. These sophisticated models allow to better integrate the influence of microenvironmental conditions in

Last updated on: 23-02-2024 - 16:20

Contact: Cyril Corbet
Organisation: Université Catholique de Louvain (UCL)
Status: Published in peer reviewed journal
Adult intestinal stem cells are grown into closed 3D structures with protruding buds and a luminal compartment. These 3D structures are produced from the stem cells present in the base of crypts isolated from rectal mucosa samples that can be collected by suction or forceps biopsy. The crypts are

Last updated on: 22-02-2024 - 11:15

Contact: Anabela Ramalho
Organisation: Katholieke Universiteit Leuven (KUL)
Status: Published in peer reviewed journal
Drug-induced phospholipidosis (DIPL) is a metabolic disorder characterized by an excessive intracellular accumulation of phospholipids caused by cationic drugs. Hepatic cells derived from human skin are evaluated as an in vitro model to investigate DIPL and its mechanisms. Human skin stem cells

Last updated on: 20-02-2024 - 11:27

Contact: Cannot be disclosed
Organisation: Vrije Universiteit Brussel (VUB)
Status: History of use
The application of liver organoids is very promising in the field of liver tissue engineering; however, it is still facing some limitations. One of the current major limitations is the matrix in which they are cultured. The mainly undefined and murine-originated tumor matrices derived from

Last updated on: 22-01-2024 - 17:28

Organisation: Ghent University (UGent)
Status: Published in peer reviewed journal
The culture of primary human synoviocytes provides an excellent cellular model for studying the normal and pathological physiology of synoviocytes and the development of joint diseases. Human primary synoviocytes can either be provided by commercial suppliers or isolated from fresh biological

Last updated on: 17-01-2024 - 11:32

Contact: Julie Uerlings
Organisation: ARTIALIS
Status: History of use, Internally validated
Method to culture human epidermal keratinocytes and seed them for tissue reconstruction at the air-liquid interface over a polycarbonate porous membrane.

Last updated on: 19-12-2023 - 19:19

Contact: Yves Poumay
Organisation: Université de Namur (UNamur)
Status: Published in peer reviewed journal
Fiber biopersistence is a key factor in understanding the pathogenicity of man-made vitreous fibres (MMVF). Today, compliance to Note Q in Annex VI of Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures may only be demonstrated via in vivo

Last updated on: 19-12-2023 - 19:17

Contact: Léa Hiéronimus
Organisation: Eurima is the European Insulation Manufacturers Association
Status: Still in development, Internally validated, Published in peer reviewed journal
Alkaptonuria (AKU) is a rare inborn error of metabolism caused by a defective homogentisate 1,2-dioxygenase (HGD), an enzyme involved in the tyrosine degradation pathway. Loss of HGD function leads to the accumulation of homogentisic acid (HGA) in connective body tissues in a process called

Last updated on: 06-12-2023 - 14:45

Contact: Sien Lequeue
Organisation: Vrije Universiteit Brussel (VUB)
Partners: RWTH Aachen
Status: Published in peer reviewed journal
More than 3 million deaths worldwide are linked to excessive alcohol consumption. Alcohol abuse associated gut barrier dysfunction is thought to play an important role in the development of alcohol-associated liver disease. Although some aspects that contribute to this process have been elucidated,

Last updated on: 30-10-2023 - 10:05

Organisation: Université Catholique de Louvain (UCL)
Partners: UCLouvain, Cliniques universitaires Saint-Luc, UCLouvain
Status: Still in development